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The optimal intensity of anticoagulation was found to lie between an INR of 2.0 and an INR of 3.9.No treatment effect was apparent with anticoagulation below an INR of 2.0.The rate of thromboembolic events was lowest in INRs from 2.0 to 3.9,and most major bleeding complications occurred with treatment at intensities with INRs of 5.0 or above.To achieve optimal levels of anticoagulation with the lowest risk in patients with atrial fibrillation and a recent episode of cerebral ischemia,the target value for the INR should be set at 3.0,and values below 2.0 and above 5.0 should be avoided. |
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